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verapamil hydrochloride

PHARMACOLOGICAL ACTION:
Verapamil is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist) which exerts its pharmacological effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and contractile myocardial cells. Verapamil reduces myocardial oxygen consumption in vitro directly by intervening in the energy consuming metabolic process of the myocardial cell, and indirectly by diminishing the peripheral resistance (afterload). It prolongs impulse conduction in the AV node.

INDICATIONS:
Angina pectoris, mild to moderate hypertension, supraventricular tachydysrhythmia.
Prophylaxis of supraventricular relapses after electrocardioversion.

CONTRA-INDICATIONS:
Hypotension associated with cardiogenic shock. Heart failure. Retarded AV conduction (second and third degree AV block); acute stage of myocardial infarction; sick sinus syndrome.
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