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NEOMERCAZOLE®

COMPOSITION:
Each tablet contains:
Carbimazole 5 mg

PHARMACOLOGICAL ACTION:
Carbimazole is an anti-thyroid substance which depresses the formation of thyroid hormone. It reduces the uptake and concentration of inorganic iodine by the thyroid but its main effect is to reduce the formation of di-iodotyrosine and thyroxine. Carbimazole is absorbed rapidly from the gastro-intestinal tract and is widely distributed throughout the body. Carbimazole is completely metabolised to methimazole and it is the metabolite that is responsible for its clinical activity.
Carbimazole readily crosses the placental barrier and also attains a high concentration in the milk of lactating patients.
Excretion in the urine is rapid. The elimination half-life of methimazole may be increased in hepatic and renal impairment.

INDICATIONS:
NeoMercazole tablets are indicated in the management of hyperthyroidism, thyrotoxicosis (including thyroid storm), and also for the preparation of patients for thyroidectomy.
NeoMercazole tablets can also be used in combination with radio-active ablative therapy.

CONTRA-INDICATIONS:
Hypersensitivity to carbimazole or other thiourea antithyroid agents.
Carbimazole should be given with the utmost caution, or not at all, if there is any degree of tracheal obstruction, as high dosages may produce thyroid enlargement and obstructive symptoms may become marked.

DOSAGE AND DIRECTIONS FOR USE:
10 mg to 60 mg daily according to the severity of the disorder. The dose should be gradually reduced to the smallest amount which will control the disease. Daily dosage should be divided.
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