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ALDACTONE® 25 Tablets / ALDACTONE® 100 Tablets

COMPOSITION :
ALDACTONE 25: Each tablet contains 25 mg
spironolactone
ALDACTONE 100: Each tablet contains 100 mg spironolactone

PHARMACOLOGICAL CLASSIFICATION:
A18.1 Diuretics.

PHARMACOLOGICAL ACTION:
ALDACTONE promotes diuresis in patients with oedema or ascites. ALDACTONE acts in the distal portion of the renal tubule by competitive inhibition of aldosterone, a sodium-retaining, potassium-excreting hormone.

INDICATIONS:
Congestive cardiac failure, hepatic cirrhosis with ascites and oedema, the nephrotic syndrome, idiopathic oedema including premenstrual oedema, malignant ascites, essential hypertension, pre-operative management of primary aldosteronism, long-term treatment of primary aldosteronism where the patient is unable or unwilling to undergo surgery, as an aid to the diagnosis of mineralocorticoid excess, including primary aldosteronism.

CONTRA-INDICATIONS:
ALDACTONE should not be given in acute renal insufficiency, rapidly progressing impairment of renal function, anuria or hyperkalaemia.

WARNINGS:
Administration is not recommended in the presence of raised serum potassium and the concomitant use of triamterene or amiloride should be avoided as hyperkalaemia may be induced. The use of potassium supplements is also not recommended for the same reason, except in cases of initial potassium depletion.
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